ubiquitin-activating enzyme E1-like protein 2; monocyte protein 4; MOP-4 (UBE1L2, UBA6, MOP4)

Function: - activates ubiquitin by first adenylating its carboxy-terminal Gly with ATP & linking it to Cys in E1, yielding an ubiquitin-E1 thioester & free AMP - isoform 2 may play a key role in ubiquitin system & may influence spermatogenesis & male fertility - role in ubiquitin conjugation, 1st step Structure: belongs to the ubiquitin-activating E1 family Alternative splicing: named isoforms=4 Expression: - isoform 2 is predominantly expressed in testis - higher expression in adult testis than in fetal testis

Properties

SIZE: MW = 118 kD entity length = 1052 aa MOTIF: ATP-binding site NAME: ATP-binding site SITE: 470-500 cysteine residue {C625}

References

UniProt :accession A0AVT1