U4/U6-snRNP; U4/U6 small nuclear ribonucleoprotein

Occurs as complex.

Properties

COMPARTMENT: cell nucleus SUBUNITS: U4-snRNA MOTIF: Sm binding site EFFECTOR-BOUND: Sm protein BOUND-VIA: RNA-binding motif inverted GTP 5' cap structure 2,2,7 trimethylated inverted GTP 5' cap structure U6-snRNA MOTIF: inverted GTP 5' cap structure U1/U2-E protein U4/U6 small nuclear ribonucleoprotein Prp3 MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid valine residue {579-584} (6) U4/U6 small nuclear ribonucleoprotein Prp4 MOTIF: WD repeat {229-268} WD repeat {271-318} WD repeat {321-360} WD repeat {363-402} WD repeat {405-444} WD repeat {447-487} WD repeat {490-521} U6 snRNA-associated Sm-like protein LSm2 MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid U6 snRNA-associated Sm-like protein LSm3 MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid U6 snRNA-associated Sm-like protein LSm6 MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid U6 snRNA-associated Sm-like protein LSm7 MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid U6 snRNA-associated Sm-like protein LSm8 (NAA38) MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid

References

- Bindereif A, Wolff T, Green MR. Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexes. EMBO J. 1990 Jan;9(1):251-5. PMID: 2136831

Components

U1/U2-E protein (snRPE) U4-snRNA U4/U6 small nuclear ribonucleoprotein Prp3; pre-mRNA splicing factor 3; U4/U6 snRNP 90 kD protein; hPrp3 (PRPF3) U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kD protein; WD splicing factor Prp4; hPrp4 (PRPF4) U6 snRNA-associated Sm-like protein LSm2 (small nuclear ribonuclear protein D homolog, G7b, SnRNP core SM-like protein SM-x5, LSM2, C6orf28, G7B) U6 snRNA-associated Sm-like protein LSm3 (MDS017) U6 snRNA-associated Sm-like protein LSm6 (Sm protein F) U6 snRNA-associated Sm-like protein LSm7 U6 snRNA-associated Sm-like protein LSm8 (NAA38) U6-snRNA