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fibrillarin (U3 RNP) Ab in serum

Epidemiology: - more common in black men [1] Pinciple: - anti-fibrillarin Ab Clinical significance: - associated with poor outcomes in scleroderma a) scleroderma complicated by pulmonary hypertension b) diffuse cutaneous scleroderma c) scleroderma complicated by myositis - speckled antinuclear antibody pattern

Related

rRNA 2'-O-methyltransferase fibrillarin; 34 kD nucleolar scleroderma antigen (FBL, FIB1, FLRN) U3-snRNP; U3 small nuclear ribonucleoprotein

Specific

fibrillarin (U3 RNP) IgG in serum

General

RNP Ab in serum

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 16, 17 American College of Physicians, Philadelphia 2012, 2015