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U2-snRNP; U2 small nuclear ribonucleoprotein

U2 binds to branch site.

Related

U2 RNP Ab in serum

General

small nuclear ribonucleoprotein (snRNP)

Properties

COMPARTMENT: cell nucleus SUBUNITS: U2-snRNA MOTIF: Sm binding site EFFECTOR-BOUND: Sm protein BOUND-VIA: RNA-binding motif inverted GTP 5' cap structure 2,2,7 trimethylated inverted GTP 5' cap structure U2-A' protein MOTIF: RNP motif NAME: RNP motif (2) FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif U2-B'' protein MOTIF: RNP motif NAME: RNP motif (2) FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif U1/U2-E protein U2 auxilary factor MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid splicing factor 3A COMPARTMENT: cell nucleus MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid splicing factor 3B COMPARTMENT: cell nucleus MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid

References

  1. Bindereif A, Wolff T, Green MR. Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexes. EMBO J. 1990 Jan;9(1):251-5. PMID: 2136831
  2. Nagai K, Oubridge C, Jessen TH, Li J, Evans PR. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature. 1990 Dec 6;348(6301):515-20. PMID: 2147232

Component-of

spliceosome

Components

small nuclear ribonucleoprotein U2B'' (SNRPB2) splicing factor 3A (SF3A) splicing factor 3B (SF3B) splicing factor U2 auxiliary factor U1/U2-E protein (snRPE) U2-A' protein (SNRPA1) U2-snRNA