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tyrosine kinase (protein tyrosine kinase, PTK)
Function:
- protein tyrosine kinases do not occur in yeast, & as tyrosine kinases in eukaryotes seem to play a role in signal transduction, it is speculated that tyrosine kinases may have evolved to play a role in cell-cell communication
Interactions
molecular events
Related
Tyrosine phosphorylation site
Specific
abl protein
activated CDC42 kinase 1; ACK-1; tyrosine kinase non-receptor protein 2 (TNK2, ACK1)
Bruton tyrosine kinase; agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor tyrosine kinase (BPK, BTK, AGMX1)
c-src kinase (CSK) or protein tyrosine kinase CYL
dual specificity protein kinase CLK4; CDC-like kinase 4 (CLK4)
dual specificity protein kinase TTK; phosphotyrosine picked threonine-protein kinase; PYT (TTK, MPS1, MPS1L1)
dual-specificity tyrosine-phosphorylation regulated kinase
dual-specificity tyrosine-phosphorylation regulated kinase 1A (protein kinase minibrain homolog, MNBH, HP86, dual specificity YAK1-related kinase, Dyrk1A)
focal adhesion kinase (FAK)
fps protein or fes protein
IL2-inducible T-cell kinase
insulin receptor beta (INSRA)
Janus kinase (JAK)
membrane-associated tyrosine-& threonine-specific cdc2-inhibitory kinase; Myt1 kinase (PKMYT1, MYT1)
mitogen activated protein kinase kinase (MAP2K), MAPK/ERK kinase (MEK)
mitogen-activated protein kinase kinase kinase 10 (MAP3K10, mixed lineage kinase [MLK] 2, MLK2, MST)
mitogen-activated protein kinase kinase kinase 9 (MAP3K9, mixed lineage kinase [MLK] 1, MLK1, PRKE1)
nim1 kinase
non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1 (TNK1)
p21rho G-associated kinase [ACK] or CDC42Hs-associated kinase
p75 liver tyrosine kinase
protein kinase CLK (cdc-like kinase)
protein tyrosine kinase 6; breast tumor kinase; tyrosine protein kinase BRK (PTK6 BRK)
serine/threonine protein kinase ULK2; Unc-51-like kinase 2 (ULK2, KIAA0623)
spleen tyrosine kinase (Syk)
src proto-oncogene protein family
Tec tyrosine kinase (TEC, PSCTK4)
thymic p40 tyrosine kinase
titin (connectin, rhabdomyosarcoma antigen MU-RMS-40.14, TTN)
tubulin-tyrosine ligase (TTL)
TXK tyrosine kinase (TXK, PTK4)
tyrosine kinase CTK; protein kinase HYL; hematopoietic consensus tyrosine-lacking kinase; protein kinase MATK; megakayrocyte-associated protein kinase (MATK, CTK, HYL)
tyrosine kinase receptor (RTK)
tyrosine protein kinase 7; colon carcinoma kinase 4; CCK-4; protein tyrosine kinase 7; pseudo tyrosine kinase receptor 7; tyrosine protein kinase-like 7 (PTK7, CCK4)
tyrosine-protein kinase FRK; FYN-related kinase; nuclear tyrosine protein kinase RAK (FRK, PTK5, RAK)
tyrosine-protein kinase SgK223 (Sugen kinase 223, SGK223)
tyrosine-protein kinase SgK269 (PEAK1)
tyrosine-protein kinase Srms (SRMS, C20orf148)
tyrosine-protein kinase STYK1; novel oncogene with kinase domain; protein PK-unique; serine/threonine/tyrosine kinase 1 (STYK1, NOK)
wee1 proto-oncogene protein
Wee1-like protein kinase 1B; Wee1B kinase (WEE1B, WEE2)
X-linked bone marrow [BMX] tyrosine kinase; epithelial & endothelial tyrosine kinase (BMX, ETK, NTK38)
Zap-70 tyrosine kinase; zeta-associated protein 70 kD; Syk-related tyrosine kinase (ZAP70, SRK)
General
protein kinase
Properties
STATE: active state
MOTIF: Tyr phosphorylation site
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Database Correlations
ENZYME 2.7.1.112
References
- Hanks SK, Quinn AM, Hunter T.
The protein kinase family: conserved features and deduced
phylogeny of the catalytic domains.
Science. 1988 Jul 1;241(4861):42-52. Review.
PMID: 3291115