Search
tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase, TAT)
Function:
- catalyzes the 1st step in the catabolism of tyrosine, the reversible transfer of the amino group of tyrosine to 2-oxo-glutarate to form 4-hydroxyphenylpyruvate & L-glutamate
- amino-acid degradation; L-phenylalanine degradation
- acetoacetate & fumarate from L-phenylalanine: step 2/6
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
Cofactor: pyridoxal phosphate (putative)
Structure:
- homodimer (putative)
- belongs to the class-1 pyridoxal-phosphate-dependent aminotransferase family
Pathology:
- defects in TAT are the cause of tyrosinemia type 2
Related
TAT gene mutation
tyrosine aminotransferase gene
tyrosinemia type 2 (Richner-Hanhart syndrome)
General
aminotransferase
Properties
SIZE: entity length = 454 aa
MW = 50 kD
MOTIF: cofactor-binding site [280-280]
FOR-BINDING-OF: pyridoxal phosphate
Database Correlations
OMIM 276600
UniProt P17735
PFAM correlations
KEGG correlations
ENZYME 2.6.1.5
References
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
- UniProt :accession P17735
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TAT