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collagen type-9 (FACIT collagen)
Function:
- a structural component of hyaline cartilage & vitreous of the eye
- covalently linked to the telopeptides of type 2 collagen by Lys-derived cross-links
Structure:
- heterotrimer of an COL9A1, COL9A2 & COL9A3
General
collagen
Properties
COMPARTMENT: extracellular matrix
WITHIN: cartilage
SUBUNITS: collagen 9 alpha-1
MOTIF: signal sequence {1-23}
Nonhelical region (NC4) {24-268}
MOTIF: cysteine residue {C44}
MODIFICATION: cysteine residue {C242}
TSP N-terminal {50-244}
N-glycosylation site {N171}
cysteine residue {C198}
MODIFICATION: cysteine residue {C252}
Zn+2-binding site
SITE: 213-213
Zn+2-binding site
SITE: 215-215
cysteine residue {C242}
MODIFICATION: cysteine residue {C44}
cysteine residue {C252}
MODIFICATION: cysteine residue {C198}
Zn+2-binding site
SITE: 253-253
Triple-helical region (COL3) {269-405}
Nonhelical region (NC3) {406-417}
MOTIF: cysteine residue {C411}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C415}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Triple-helical region (COL2) {418-756}
Nonhelical region (NC2) {757-786}
Triple-helical region (COL1) {787-901}
Nonhelical region (NC1) {902-921}
collagen 9 alpha-2
MOTIF: signal sequence {1-23}
Triple-helical region 4 (COL4) {27-163}
Nonhelical region 4 (NC4) {164-180}
MOTIF: Ser glycosylation site {S169}
cysteine residue {C174}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C178}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Triple-helical region 3 (COL3) {181-519}
Nonhelical region 3 (NC3) {520-549}
Triple-helical region 2 (COL2) {550-632}
Nonhelical region 2 (NC2) {633-634}
Triple-helical region 1 (COL1) {635-664}
Nonhelical region 1 (NC1) {665-689}
collagen 9 alpha-3
MOTIF: signal sequence {1-25}
Triple-helical region 3 (COL3) {29-519}
MOTIF: Cell attachment site {423-425}
N-glycosylation site {N483}
Nonhelical region 3 (NC3) {520-550}
Triple-helical region 2 (COL2) {551-630}
MOTIF: Cell attachment site {601-603}
Nonhelical region 2 (NC2) {631-632}
Triple-helical region 1 (COL1) {633-661}
Nonhelical region 1 (NC1) {662-684}
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 906
- Wikipedia, collagen entry
http://en.wikipedia.org/wiki/collagen
Components
collagen 9 alpha-1 (COL9A1)
collagen 9 alpha-2 (COL9A2)
collagen 9 alpha-3 (COL9A3)