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collagen type-12
Function:
- interacts with collagen type-1
- interacts with decorin & glycosaminoglycans
Structure:
- may contain homotrimers of either COL12A1 isoform 1 or COL12A1 isoform 2 or any combination of isoform 1 & isoform 2
General
collagen
Properties
COMPARTMENT: extracellular matrix
SUBUNITS: collagen 12 alpha-1
MOTIF: signal sequence {1-24}
fibronectin type III domain or F3 module {25-112}
VWFA domain {140-316}
fibronectin type III domain or F3 module {333-422}
VWFA domain {440-616}
fibronectin type III domain or F3 module {631-719}
MOTIF: N-glycosylation site {N700}
fibronectin type III domain or F3 module {722-810}
MOTIF: Ser glycosylation site {S798}
fibronectin type III domain or F3 module {813-901}
MOTIF: Cell attachment {862-864}
Ser glycosylation site {S889}
fibronectin type III domain or F3 module {904-993}
MOTIF: Ser glycosylation site {S981}
fibronectin type III domain or F3 module {995-1083}
fibronectin type III domain or F3 module {1086-1175}
VWFA domain {1199-1371}
fibronectin type III domain or F3 module {1384-1472}
fibronectin type III domain or F3 module {1474-1563}
fibronectin type III domain or F3 module {1565-1652}
fibronectin type III domain or F3 module {1654-1743}
fibronectin type III domain or F3 module {1752-1841}
MOTIF: N-glycosylation site {N1763}
fibronectin type III domain or F3 module {1843-1931}
fibronectin type III domain or F3 module {1933-2022}
fibronectin type III domain or F3 module {2024-2113}
fibronectin type III domain or F3 module {2115-2202}
fibronectin type III domain or F3 module {2206-2290}
MOTIF: N-glycosylation site {N2206}
VWFA domain {2323-2496}
Nonhelical region (NC3) {2451-2746}
MOTIF: TSP N-terminal {2520-2712}
N-glycosylation site {N2528}
N-glycosylation site {N2679}
Triple-helical region (COL2) with 1 imperfection {2747-2898}
MOTIF: Cell attachment {2779-2781}
Cell attachment {2895-2897}
Nonhelical region (NC2) {2899-2941}
Triple-helical region {2942-3044}
Nonhelical region (NC1) {3045-3063}
References
- UniProt :accession Q99715
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 906
Components
collagen 12 alpha-1 (COL12A1)