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thioredoxin-1 (ATL-derived factor, ADF, surface-associated sulfhydryl protein, SASP, TRX1, TXN, TRDX)
Function:
- role in redox reactions through reversible oxidation of its active center dithiol to a disulfide
- catalyzes dithiol-disulfide exchange reactions
- augments expression of IL2 receptor TAC (IL2R/P55)
Structure:
- homodimer
- interacts with TXNIP through the redox-active site
- belongs to the thioredoxin family
- contains 1 thioredoxin domain
Compartment: cytoplasm
Related
thioredoxin domain-containing protein
thioredoxin-like protein
General
thioredoxin-1 (TRX)
Properties
SIZE: entity length = 105 aa
MW = 12 kD
COMPARTMENT: cytoplasm
MOTIF: thioredoxin domain
SITE: 2-105
MOTIF: cysteine residue {C32}
MODIFICATION: cysteine residue {C35}
proton acceptor {26-26}
cysteine residue {C32}
redox potential {33-33}
redox potential {34-34}
cysteine residue {C35}
cysteine residue {C35}
MODIFICATION: cysteine residue {C32}
cysteine residue {C73}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Thr phosphorylation site {T100}
Database Correlations
OMIM 187700
UniProt P10599
Pfam PF00085
Kegg hsa:7295
References
UniProt :accession P10599