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caspase-4; ich-2 protease; Tx protease (CASP4, ICH2)
Function:
- role in the activation cascade of caspases responsible for apoptosis execution
- cleaves caspase-1 heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small & a large subunit (putative)
- the two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8
- strict requirement for Asp at the P1 position
- preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-
Structure:
- belongs to the peptidase C14 family
- contains 1 CARD domain
Expression:
- widely expressed
- spleen & lung > heart & liver > skeletal muscle, kidney & testis
- not found in brain
Interactions
molecular events
Specific
proich 2
General
caspase; cysteinyl aspartate-specific proteinase; ICE/CED3 family protease
Properties
SIZE: entity length = 377 aa
MW = 43 kD
MOTIF: CARD domain {1-91}
histidine residue {H210}
cysteine residue {C258}
Database Correlations
OMIM 602664
UniProt P49662
PFAM correlations
Entrez Gene 837
Kegg hsa:837
ENZYME 3.4.22.57
References
- Martin SJ, Green DR.
Protease activation during apoptosis: death by a thousand cuts?
Cell. 1995 Aug 11;82(3):349-52. Review. No abstract available.
PMID: 7634323
- UniProt :accession P49662