neuronal tubulin polyglutamylase complex

Function: - forms polyglutamate side chains on tubulin - may catalyze ligation of Gly to tubulin Structure: - consists of: - C19orf20/PGs1, C18orf10/PGs2, TTLL1, LRRC49 & NICN1

General

molecular complex tubulin polyglutamylase

Properties

MOTIF: active site SUBUNITS: tubulin polyglutamylase complex subunit 1 COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S266} tubulin polyglutamylase complex subunit 2 COMPARTMENT: cell nucleus tubulin-tyrosine ligase-like protein 1 MOTIF: TTL {1-367} leucine-rich repeat-containing protein 49 MOTIF: leucine-rich repeat SITE: 111-133 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 134-154 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 155-176 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 177-201 MOTIF: leucine residue (SEVERAL) consensus repeat {201-221} SEQUENCE-IS: LLR leucine-rich repeat SITE: 221-245 MOTIF: leucine residue (SEVERAL) coiled coil {303-341} leucine-rich repeat SITE: 397-420 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 635-658 MOTIF: leucine residue (SEVERAL) nicolin-1 COMPARTMENT: cell nucleus

References

UniProt :accession O95922

Components

leucine-rich repeat-containing protein 49 (tubulin polyglutamylase complex subunit 4, PGs4, LRRC49) nicolin-1 (tubulin polyglutamylase complex subunit 5, PGs5, NPCEDRG) (NICN1) tubulin polyglutamylase complex subunit 1 (TPGS1, PGs1, C19orf20) tubulin polyglutamylase complex subunit 2 (TPGS2, PGs2, C18orf10) tubulin-tyrosine ligase-like protein 1 (tubulin polyglutamylase, tubulin polyglutamylase complex subunit 3, PGs3, TTLL1, C22orf7)