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tubulin
Function:
- major constituent of microtubules
- binds two moles of GTP, one at an exchangeable site on the beta-chain & one at a non-exchangeable site on the alpha-chain
Structure: dimer of alpha & beta chains
Interactions
molecular events
General
calmodulin binding protein
microtubule protein
multisubunit protein
PEST protein
Properties
COMPARTMENT: cytoplasm
MOTIF: calmodulin binding site
FOR-BINDING-OF: calmodulin
PEST region
SUBUNITS: tubulin alpha
MOTIF: GTP-binding site
SITE: N
GTP-binding site
SITE: E
domain
MOTIF: glycine residue (SEVERAL)
beta tubulin
MOTIF: mRNA autoregulation signal {N-TERMINUS}
MOTIF-SEQUENCE:
GTP-binding site
SITE: N
GTP-binding site
SITE: E
domain
MOTIF: glycine residue (SEVERAL)
References
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
Component-of
molecular complex
Components
beta tubulin
tubulin alpha