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RhoH protein; Rho-related GTP-binding protein RhoH; GTP-binding protein TTF; translocation three-four (RhoH, ARHH, TTF)
Structure:
- belongs to the small GTPase superfamily, Rho family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative)
Expression: transcribed only in hemopoietic cells
Pathology:
- chromosomal translocation t(3;4)(q27;p11) involving RhoH with with BCL6 is found in a non-Hodgkin lymphoma cell line
General
rho subfamily protein
Properties
SIZE: entity length = 191 aa
MW = 21 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 11-18
Effector region {33-41}
GTP-binding site
SITE: 58-62
GTP-binding site
SITE: 116-119
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 602037
UniProt Q15669
Pfam PF00071
Entrez Gene 399
Kegg hsa:399
References
- UniProt :accession Q15669
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/RHOH93.html
- OMIM :accession 602037
- Entrez Gene :accession 399