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pituitary adenoma/TSH secreting
Pathology:
-> tumors are generally large when found (macroadenoma)
Clinical manifestations:
- manifestations of hyperthyroidism
Laboratory:
1) elevated serum free T4
2) normal or high serum TSH
Radiology:
- CT or MRI of hypothalamus & pituitary
Management:
1) trans-sphenoidal surgery
a) treatment of choice
b) rarely results in cure
2) somatostatin analogs
a) most patients respond to octreotide
b) lanreotide
Related
hyperthyroidism
octreotide (Sandostatin)
thyroid-stimulating hormone (TSH) or thyrotropin
General
pituitary adenoma
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 17, 18.
American College of Physicians, Philadelphia 1998, 2009, 2015, 2018.
- Malchiodi E, Profka E, Ferrante E et al
Thyrotropin-secreting pituitary adenomas: outcome of pituitary
surgery and irradiation.
J Clin Endocrinol Metab. 2014 Jun;99(6):2069-76.
PMID: 24552222
- Amlashi FG, Tritos NA.
Thyrotropin-secreting pituitary adenomas: epidemiology, diagnosis, and management.
Endocrine. 2016 Jun;52(3):427-40. Review.
PMID: 26792794