thyroid-stimulating hormone (TSH) or thyrotropin

Function: - stimulates thyroxine secretion by the thyroid Compartment: secreted Expression: secreted by the anterior pituitary Biochemistry: - carbohydrate sulfotransferase (CHST8, CHST9) required for biosynthesis of thyrotropin Pathology: - anti-thyrotropin Ab in Graves disease - deficiency associated with secondary hypothyroidism - overproduction associated with secondary hyperthyroidism (rare) & (more commonly) a physiologic response to primary hypothyroidism Laboratory: - thyrotropin in blood - thyrotropin in blood spot - thyroid-stimulating hormone in saliva - thyroid-stimulating hormone in serum - thyrotropin Ag in tissue - thyrotropin Ab in serum

Related

pituitary adenoma/TSH secreting thyroid-stimulating hormone (TSH) in serum; thyrotropin in serum thyrotropin Ag in tissue thyrotropin receptor; thyroid-stimulating hormone receptor; TSH-R (TSHR LGR3) thyrotropin-releasing hormone; thyroliberin; protirelin (TRH) thyroxine (T4) triiodothyronine (T3, liothyronine, Cytomel)

General

anterior pituitary hormone glycoprotein multisubunit protein

Properties

COMPARTMENT: plasma MOTIF: glycosylation site SUBUNITS: glycoprotein hormone alpha chain MOTIF: cysteine residue {C31} MODIFICATION: cysteine residue {C55} cysteine residue {C34} MODIFICATION: cysteine residue {C84} cysteine residue {C52} MODIFICATION: cysteine residue {C106} cysteine residue {C55} MODIFICATION: cysteine residue {C31} cysteine residue {C56} MODIFICATION: cysteine residue {C108} N-glycosylation site {N76} cysteine residue {APP C83 peptide fragment SIZE: entity length = 83 aa} MODIFICATION: cysteine residue {C111} cysteine residue {C84} MODIFICATION: cysteine residue {C34} N-glycosylation site {N102} cysteine residue {C106} MODIFICATION: cysteine residue {C52} cysteine residue {C108} MODIFICATION: cysteine residue {C56} cysteine residue {C111} MODIFICATION: cysteine residue {APP C83 peptide fragment SIZE: entity length = 83 aa} TSH-beta MOTIF: cysteine residue {C22} MODIFICATION: cysteine residue {C72} cysteine residue {C36} MODIFICATION: cysteine residue {C87} cysteine residue {C39} MODIFICATION: cysteine residue {C125} N-glycosylation site {N43} cysteine residue {C47} MODIFICATION: cysteine residue {C103} cysteine residue {C51} MODIFICATION: cysteine residue {C105} cysteine residue {C72} MODIFICATION: cysteine residue {C22} cysteine residue {C87} MODIFICATION: cysteine residue {C36} cysteine residue {C103} MODIFICATION: cysteine residue {C47} cysteine residue {C105} MODIFICATION: cysteine residue {C51} cysteine residue {C108} MODIFICATION: cysteine residue {C115} cysteine residue {C115} MODIFICATION: cysteine residue {C108} cysteine residue {C125} MODIFICATION: cysteine residue {C39}

Components

glycoprotein hormone alpha chain thyroid-stimulating hormone [TSH]-beta chain (thyrotropin beta chain, TSHB)