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trypsin-3; brain trypsinogen; mesotrypsinogen; serine protease 3; serine protease 4; trypsin III; trypsin IV (PRSS3, PRSS4, TRY3, TRY4)
Function:
- digestive protease specialized for degradation of trypsin inhibitors
- in the ileum, may be involved in defensin processing, including DEFA5
- preferential cleavage: Arg-|-Xaa, Lys-|-Xaa
Cofactor: binds 1 Ca+2 per subunit
Structure:
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
Compartment: secreted
Alternative splicing: named isoforms=4; A, B, C, D
Expression:
- expressed in pancreas & brain
- also expressed in paneth cells, at the base of small intestinal crypts
General
Ca+2 binding protein
trypsin
Properties
SIZE: entity length = 304 aa
MW = 33 kD
COMPARTMENT: extracellular compartment
MOTIF: S1 domain {81-301}
MOTIF: cysteine residue {C87}
MODIFICATION: cysteine residue {C217}
cysteine residue {C105}
MODIFICATION: cysteine residue {C121}
histidine residue {H120}
cysteine residue {C121}
MODIFICATION: cysteine residue {C105}
Ca+2-binding site
SITE: 132-132
Ca+2-binding site
SITE: 134-134
Ca+2-binding site
SITE: 137-137
Ca+2-binding site
SITE: 142-142
aspartate residue {D164}
cysteine residue {C196}
MODIFICATION: cysteine residue {C263}
cysteine residue {C217}
MODIFICATION: cysteine residue {C87}
cysteine residue {C228}
MODIFICATION: cysteine residue {C242}
cysteine residue {C242}
MODIFICATION: cysteine residue {C228}
aspartate residue {251}
cysteine residue {C253}
MODIFICATION: cysteine residue {C277}
serine residue {S257}
cysteine residue {C263}
MODIFICATION: cysteine residue {C196}
cysteine residue {C277}
MODIFICATION: cysteine residue {C253}
STATE: active state
Database Correlations
OMIM 613578
UniProt P35030
Pfam PF00089
Entrez Gene 5646
Kegg hsa:5646
ENZYME 3.4.21.4
References
UniProt :accession P35030