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trovafloxacin (Trovan)
Tradename: Trovan. (trovafloxacin mesylate) Restricted use by FDA, 1999 (hospitals & nursing homes)
Indications:
- acute bacterial exacerbations of chronic bronchitis
- community acquired pneumonia
- nosocomial pneumonia
- acute sinusitis
- complicated intra-abdominal infections
- bacterial peritonitis
- postoperative infections
- gynecologic & pelvic infections
- endometritis
- parametritis
- septic abortion
- post-partum infections
- prophylaxis of infection associated with elective colorectal surgery, vaginal & abdominal hysterectomy
- uncomplicated skin & skin structure infections
- complicated skin & skin structure infections
- diabetic foot infections
- cellulitis
- uncomplicated urinary tract infection (cystitis)
- chronic bacterial prostatitis
- uncomplicated urethral gonorrhea in males & endocervical & rectal gonorrhea in females
- Cervicitis
- pelvic inflammatory disease (mild to moderate)
Dosage: 200-300 mg PO QD.
Tabs: 100 & 200 mg.
IV form is L-alanyl-L-alanyl derivative alatrofloxacin.
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus pneumoniae
- Streptococcus pyogenes
- Streptococcus agalactiae
- Streptococcus viridans
- Enterococcus faecalis
- Staphylococcus
- Staphylococcus aureus
- Staphylococcus epidermidis
Gram negative
- Haemophilus influenzae
- Moraxella catarrhalis
- Haemophilus parainfluenzae
- Mycoplasma pneumonia
- Legionella pneumophila
- Chlamydia pneumoniae
- Escherichia coli
- Pseudomonas aeruginosa
- Bacteroides fragilis
- Klebsiella pneumonia
- Prevotella species
- Proteus mirabilis
- Neisseria gonorrhoeae
- Chlamydia trachomatis
- Gardnerella vaginalis
Anaerobes
- Peptostreptococcus species
Adverse effects:
1) not common 1-9%
- dizziness, lightheadedness, nausea, headache, vomiting, diarrhea, abdominal pain, vaginitis, pruritus, rash
2) uncommon <1%
- many, including acute liver failure
Interactions
drug interactions
drug adverse effects of fluoroquinolones
Related
alatrofloxacin (Trovan IV)
General
fluoroquinolone
Properties
INHIBITS: DNA gyrase
MISC-INFO: elimination route LIVER
1/2life 12-16 HOURS
Database Correlations
PUBCHEM correlations
References
- Pfizer package insert
- FDA alert 6/99, www.fda.gov