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tropomyosin alpha-1 chain; tropomyosin-1; alpha-tropomyosin (TPM1, C15orf13, TMSA)
Function:
- binds to actin filaments in muscle & non-muscle cells
- role, in association with the troponin complex, in Ca+2 dependent regulation of vertebrate striated muscle contraction
- smooth muscle contraction is regulated by interaction with caldesmon
- in non-muscle cells, implicated in stabilizing cytoskeleton actin filaments
Structure:
- heterodimer of an alpha & a beta chain
- the molecule is in a coiled coil structure that is formed by 2 polypeptide chains
- the sequence exhibits a prominent 7-residues periodicity
- belongs to the tropomyosin family
Compartment: cytoplasm, cytoskeleton
Alternative splicing: named isoforms=6; additional isoforms seem to exist
Expression:
- isoform 1 is expressed in adult & fetal skeletal muscle & cardiac muscle
- higher expression levels in cardiac muscle
- isoform 10 is expressed in adult & fetal cardiac muscle, but not in skeletal muscle
Pathology:
- detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients
- defects in TPM1 are the cause of
a) familial hypertrophic cardiomyopathy type 3
b) dilated cardiomyopathy type 1Y (CMD1Y)
General
tropomyosin-alpha; tropomyosin-1; alpha-tropomyosin
Properties
SIZE: entity length = 284 aa
MW = 33 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {1-284}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Database Correlations
OMIM correlations
MORBIDMAP 191010
UniProt P09493
Pfam PF00261
Entrez Gene 7168
Kegg hsa:7168
References
- UniProt :accession P09493
- Familial hypertrophic cardiomyopathy mutation database
http://www.angis.org.au/Databases/heart/heartbreak.html
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPM
- Harris RA et al
Cluster analysis of an extensive human breast cancer cell
line protein expression map database.
Proteomics. 2002 Feb;2(2):212-23
PMID: 11840567