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tropisetron (Navoban, Setrovel)
Marketed by Novartis in Europe, Australia, New Zealand, Japan, South Korea & the Philippines as Navoban
Marketed in several Asian countries as Setrovel
Not available in the U.S.
Indications:
- postoperative nausea & vomiting
- chemotheraoy-induced nausea & vomiting
- investigational uses
- Tanalgesia in fibromyalgia
- prevention of postoperative delirium? [2]*
* proof of effectiveness for prevention of postoperative delirium not provided
* study describes clinical trial not evidence of benefit [2]
Dosage:
- 5 mg of tropisetron IV before anesthesia induction (postoperative delirium)
Mechanism of action:
- serotonin 5-HT3 receptor antagonist
- may target alpha 7 nAChR
Related
ondansetron (Zofran)
General
anti-emetic
serotonin antagonist
Database Correlations
PUBCHEM correlations
References
- Wikipedia: Tropisetron
https://en.wikipedia.org/wiki/Tropisetron
- Sun Y, Lin D, Wang J et al
Effect of Tropisetron on Prevention of Emergence Delirium in
Patients After Noncardiac SurgeryA Trial Protocol.
JAMA Netw Open.2020;3(10):e2013443. Oct 14,
PMID: 33052400 Free PMC article.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2771448