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gestational trophoblastic disease (trophoblastic neoplasm)
Etiology:
-> encompasses spectrum of conditions
a) molar pregnancy
1] partial hydatidiform mole
2] complete hydatidiform mole
b) invasive mole (chorioadenoma destruens)
c) placental-site trophoblastic tumors
d) choriocarcinoma
Epidemiology: account for < 1% of gynecologic malignancies
Laboratory:
- see ARUP consult [2]
Management:
- potentially life threatening
- highly curable if treated early
Interactions
disease interactions
Related
pregnancy (gestation)
trophoblast
Specific
choriocarcinoma
hydatidiform (hydatid) mole (molar pregnancy)
General
placental neoplasm
References
- Cancer, Principles and Practice of Oncology; 6th ed.
deVita et al (eds); Lippincott, Williams & Wilkins, 2001, pg 1594
- ARUP Consult: Gestational Trophoblastic Disease
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/gestational-trophoblastic-disease
- Soper JT
Gestational Trophoblastic Disease: Current Evaluation and Management.
Obstet Gynecol. 2021 Feb 1;137(2):355-370.
PMID: 33416290 PMCID: PMC7813445 Free PMC article
- Lok C, Frijstein M, van Trommel N.
Clinical presentation and diagnosis of Gestational Trophoblastic Disease.
Best Pract Res Clin Obstet Gynaecol. 2021 Jul;74:42-52.
PMID: 33422446 Review.