Search
trk C protein; NT-3 growth factor receptor; neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C (NTRK3, TRKC)
Function:
- receptor for neurotrophin-3 (NT-3)
- receptor tyrosine-kinase
- known substrates for the trk receptors are SHC1, PI-3 kinase, & PLCG1
- different isoforms do not have identical signaling properties
- exists in a dynamic equilibrium between monomeric (low affinity) & dimeric (high affinity) structures
- binds SH2B2
- interacts with SQSTM1 & ARMS (putative)
- ligand-mediated auto-phosphorylation
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 2 LRR repeats (leucine-rich repeats)
- contains 1 protein kinase domain
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- widely expressed, mainly in the nervous tissue
- isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain
Interactions
molecular events
Related
NTRK3 or TRKC proto-oncogene
General
glycoprotein
leucine-rich repeat-containing protein (LRRC)
phosphoprotein
tropomyosin receptor kinase (trk) proto-oncogene protein (NTRK)
Properties
SIZE: entity length = 839 aa
MW = 94 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-31}
N-glycosylation site {N72}
N-glycosylation site {N79}
leucine-rich repeat
SITE: 102-125
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 126-149
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N133}
N-glycosylation site {N163}
N-glycosylation site {N203}
immunoglobulin superfamily domain {210-300}
MOTIF: N-glycosylation site {N218}
N-glycosylation site {N232}
N-glycosylation site {N259}
N-glycosylation site {N267}
N-glycosylation site {N272}
N-glycosylation site {N294}
immunoglobulin superfamily domain {309-382}
MOTIF: cysteine residue {C320}
MODIFICATION: cysteine residue {C362}
cysteine residue {C362}
MODIFICATION: cysteine residue {C320}
N-glycosylation site {N375}
N-glycosylation site {N388}
transmembrane domain {430-453}
tyrosine residue {516}
Tyr phosphorylation site {Y516}
kinase domain
SITE: 538-839
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 544-552
ATP-binding site
NAME: ATP-binding site
SITE: 572-572
aspartate residue {D679}
Tyr phosphorylation site {Y705}
Tyr phosphorylation site {Y709}
Tyr phosphorylation site {Y710}
tyrosine residue {834}
Tyr phosphorylation site {Y834}
Database Correlations
OMIM 191316
UniProt Q16288
PFAM correlations
ENZYME 2.7.10.1
References
- UniProt :accession Q16288
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/NTRK3ID433.html
- Lamballe F, Klein R, Barbacid M.
trkC, a new member of the trk family of tyrosine protein
kinases, is a receptor for neurotrophin-3.
Cell. 1991 Sep 6;66(5):967-79.
PMID: 1653651