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serotonin agonist (5-HT receptor agonist, triptan)
Indications:
- treatment of migraine
Contraindications:
- cardiovascular disease, including uncontrolled hypertension
- migraine with brainstem or hemiplegic aura
Adverse effects:
1) serotonin syndrome
2) reversible cerebral vasoconstriction syndrome [4]
3) triptans likely increase risk of major cardiovascular events
- incidence is low in migraine patients with elevated cardiovascular risk [6]
Drug interactions:
- use in combination with SSRI or SNRI probably does not increase risk of serotonin syndrome [5]
Interactions
drug interactions
drug adverse effects of triptan(s)
Related
serotonin [5HT] receptor
Specific
almotriptan (Axert)
eletriptan (Relpax)
frovatriptan (Frova)
lasmiditan (Reyvow)
lorcaserin (Belviq)
naratriptan (Amerge)
rizatriptan (Maxalt, Maxalt-MLT)
sumatriptan (Imitrex, migratriptan, Arcoiran, Sumavel DosePro)
zolmitriptan (Zomig)
General
anti-migraine agent
receptor agonist
References
- Prescriber's Letter 11(2):10 2004
Features of Available Triptans
Detail-Document#: 200206
(subscription needed) http://www.prescribersletter.com
- Prescriber's Letter 18(6): 2011
Comparison of Available Triptans
Detail-Document#: 270610
(subscription needed) http://www.prescribersletter.com
- Loder E.
Triptan therapy in migraine.
Engl J Med. 2010 Jul 1;363(1):63-70
PMID: 20592298
- Medical Knowledge Self Assessment Program (MKSAP) 17, 18
American College of Physicians, Philadelphia 2015, 2018
- Paauw DS
Dangerous and Deadly Drug Combinations
Medscape. June 30, 2016
http://www.medscape.com/features/slideshow/dangerous-drug-combinations
- Wang Z, VanderPluym JH, Halker Singh RB et al.
Safety of Triptans in Patients Who Have or Are at High Risk for
Cardiovascular Disease: A Target Trial Emulation.
Mayo Clin Proc. 2024 Aug 29:S0025-6196(24)00164-2
PMID: 39207344
https://www.mayoclinicproceedings.org/article/S0025-6196(24)00164-2/fulltext
- Serotonin 5-HT-Receptor Agonists
Medscape (alphabetical listing)
https://reference.medscape.com/drugs/serotonin-5-ht-receptor-agonists