Search
LIN7/CASK/APBA1 tripartite complex
Function:
- may couple synaptic vesicle exocytosis to cell adhesion in brain
Structure:
- subunits: LIN7 (LIN7A, LIN7B or LIN7C), CASK & APBA1
General
molecular complex
Properties
SUBUNITS: Lin7 homolog protein
MOTIF: binding site
FOR-BINDING-OF: protein kinase
L27
PDZ domain
NAME: PDZ domain
peripheral plasma membrane protein CASK
COMPARTMENT: cytoplasm
cell nucleus
STATE: active state
MOTIF: kinase domain
SITE: 12-276
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 18-26
ATP-binding site
NAME: ATP-binding site
SITE: 41-41
aspartate residue {D141}
Ser phosphorylation site {S151}
Ser phosphorylation site {S155}
binding site
SITE: 305-315
FOR-BINDING-OF: calmodulin
L27 1 {343-398}
L27 2 {402-455}
PDZ domain
NAME: PDZ domain
SITE: 489-564
Tyr phosphorylation site {Y571}
src homology 3 [SH3] domain
SITE: 615-682
domain {739-911}
HOMOLOGY: guanylate kinase
amyloid beta A4 protein-binding family A member 1
MOTIF: glutamate-rich region {67-70}
MOTIF: glutamate residue (SEVERAL)
Munc-18-1 binding {226-314}
MOTIF: Ser phosphorylation site {S263}
proline-rich region
SITE: 294-328
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 368-452
MOTIF: proline residue (SEVERAL)
LIN-2/CASK binding {373-436}
phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 457-643
PDZ domain
NAME: PDZ domain
SITE: 656-742
PDZ domain
NAME: PDZ domain
SITE: 747-822
References
- UniProt :accession Q9NZI8
- UniProt :accession Q9BZF9
Components
amyloid beta A4 protein-binding family A member 1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1; mint-1; adapter protein X11alpha (APBA1, MINT1, X11)
Lin7 homolog protein (LIN-7, mammalian LIN-seven protein, vertebrate LIN 7 homolog, LIN7)
peripheral plasma membrane protein CASK; hCASK; Ca+2/calmodulin-dependent serine protein kinase; protein lin-2 homolog (CASK, LIN2)