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trioxsalen; 4,5,8-trimethylpsoralen (Trisoralen)

One of two psoralens available in the US for use in PUVA treatment. Indications: - used in conjunction with ultraviolet light or sunlight for repigmentation of idiopathic vitiligo - photosensitivity - increasing tolerance to sunlight in albinism - enhance pigmentation Dosage: - adults & children > 12 years: - 10 mg PO as a single dose 2-4 hours before controlled exposure to UV-A or sunlight Tabs: 5 mg. Adverse effects: 1) common (> 10%) - itching, nausea 2) less common (1-10%) - dizziness, headache, depression, insomnia, nervousness, severe burns from excessive sunlight of ultraviolet exposure, epigastric discomfort

Related

oral psoralen & ultraviolet (UV) A light (PUVA)

General

psoralen

Database Correlations

PUBCHEM cid=5585

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996 pg 1609
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998