Search
trimethylamine
Pathology:
- proatherogenic molecule generated from dietary components by gut bacteria [1,2]
- gut bacteria convert dietary carnitine & phosphatidylcholine (lecithin) to trimethylamine-N-oxide that is absorbed
- trimethylamine is converted to trimethylamine-N-oxide by the liver & appears in plasma
Specific
trimethylamine-N-oxide (TMAO)
General
amine
Database Correlations
PUBCHEM cid=1146
References
- Tang WHW et al.
Intestinal microbial metabolism of phosphatidylcholine and
cardiovascular risk.
N Engl J Med 2013 Apr 25; 368:1575
PMID: 23614584
http://www.nejm.org/doi/full/10.1056/NEJMoa1109400
- Loscalzo J.
Gut microbiota, the genome, and diet in atherogenesis.
N Engl J Med 2013 Apr 25; 368:1647.
PMID: 23614591
http://www.nejm.org/doi/full/10.1056/NEJMe1302154
- Wang Z, Roberts AB, Buffa JA et al.
Non-lethal inhibition of gut microbial trimethylamine
production for the treatment of atherosclerosis.
Cell 2015 Dec 17; 163:1585
PMID: 26687352