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tripartite motif-containing protein 68 (Ring finger protein 137, SSA protein SS-56, SS-56, TRIM68, RNF137, SS56)
Structure:
1) belongs to the TRIM/RBCC family
2) contains 1 B box-type zinc finger
3) contains 1 B30.2/SPRY domain
4) contains 1 RING-type zinc finger
Compartment: cytoplasm, perinuclear region
Expression:
- expressed in all tissues
- high expression in spleen & in fetal liver
Pathology:
- target of immune response in patients with:
a) systemic lupus erythematosus (SLE)
b) primary Sjoegren syndrome
c) HIV-1 infection
General
tripartite motif-containing protein (trim protein)
Properties
SIZE: MW = 56 kD
entity length = 485 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RING-finger {16-61}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 93-134
EFFECTOR-BOUND: Zn+2
coiled coil {207-239}
B30.2/SPRY {285-481}
Database Correlations
UniProt Q6AZZ1
PFAM correlations
References
UniProt :accession Q495X7