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tripartite motif-containing protein 39; RING finger protein 23; testis-abundant finger protein (TRIM39, RNF23, TFP)
Function:
- may facilitate apoptosis by inhibiting the poly-ubiquitination & subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1
- interacts with MOAP1
Structure:
- belongs to the TRIM/RBCC family
- contains 1 B box-type Zn+2 finger
- contains 1 B30.2/SPRY domain
- contains 1 RING-type Zn+2 finger
Compartment:
- cytoplasm, cytosol, mitochondrion
- found predominantly in the cytosol
- partial shift from the cytosol to the mitochondria when co-localized with MOAP1
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen & testis
General
phosphoprotein
tripartite motif-containing protein (trim protein)
Properties
SIZE: entity length = 518 aa
MW = 60 kD
COMPARTMENT: mitochondria
cytoplasm
MOTIF: RING-finger {29-70}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 102-143
EFFECTOR-BOUND: Zn+2
coiled coil {181-250}
B30.2/SPRY {319-514}
MOTIF: Tyr phosphorylation site {Y439}
Database Correlations
OMIM 605700
UniProt Q9HCM9
PFAM correlations
Entrez Gene 56658
Kegg hsa:56658
References
- UniProt :accession Q9HCM9
- OMIM :accession 605700