tripartite motif-containing protein 3; RING finger protein 22; brain-expressed RING finger protein; RING finger protein 97 (TRIM3, BERP, RNF22, RNF97)

Function: - probably involved in vesicular trafficking via its association with the CART complex - associates with myosin-Vb (MYO5B) & alpha-actinin-4 (ACTN4) (putative) Structure: - interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing 6 blades (putative) - belongs to the TRIM/RBCC family - contains 1 B box-type Zn⁺² finger - contains 1 filamin repeat - contains 6 NHL repeats - contains 1 RING-type Zn⁺² finger Compartment: - cytoplasm (putative) - early endosome Alternative splicing: named isoforms=3; alpha, beta, gamma Expression: - expressed in brain, heart, uterus & testis

General

phosphoprotein tripartite motif-containing protein (trim protein)

Properties

SIZE: entity length = 744 aa MW = 81 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S7} RING-finger {22-63} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif zinc finger B box SITE: 110-151 EFFECTOR-BOUND: Zn+2 coiled coil {153-224} filamin repeat {317-418} Ser phosphorylation site {S437} Ser phosphorylation site {S443} NHL repeat domain {473-516} NHL repeat domain {520-563} NHL repeat domain {564-605} NHL repeat domain {609-652} NHL repeat domain {656-699} NHL repeat domain {700-743}

Database Correlations

OMIM 605493 UniProt O75382 PFAM correlations Entrez Gene 10612 Kegg hsa:10612

References

UniProt :accession O75382