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E3 ubiquitin-protein ligase TRIM11; tripartite motif-containing protein 11; RING finger protein 92; protein BIA1 (TRIM11, RNF92)
Function:
- may have E3 ubiquitin ligase activity
- may contribute to regulation of the intracellular level of humanin or humanin-containing proteins through the proteasomal degradation pathway
- protein modification; protein ubiquitination
- binds cytoplasmic tail of integrin alpha-1
- interacts with the humanin peptide (putative)
Structure:
- the coiled-coil domain & the B30.2 domain are both necessary for interaction with humanin (putative)
- belongs to the TRIM/RBCC family
- contains 1 B box-type Zn+2 finger
- contains 1 B30.2/SPRY domain
- contains 1 RING-type Zn+2 finger
Compartment: cytoplasm, nucleus
Alternative splicing: named isoforms=2
Expression: ubiquitous
General
ring finger protein
tripartite motif-containing protein (trim protein)
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 468 aa
MW = 53 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RING-finger {16-57}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 87-128
EFFECTOR-BOUND: Zn+2
coiled coil {129-208}
B30.2/SPRY {268-461}
Database Correlations
OMIM 607868
UniProt Q96F44
PFAM correlations
Entrez Gene 81559
Kegg hsa:81559
References
UniProt :accession Q96F44