Search
triclosan (Irgasan, Cloxifenolum, Triclosanum, Cliniclean, Cloxifenol, Tersaseptic, Aquasept, Manusept, Sapoderm)
Uses:
- used in cosmetics & toilet soaps as an antiseptic
Adverse effects:
- muscle weakness in mice [3]
- triclosan induces antibiotic tolerance in Escherichia coli & S aureus [4]
- antibiotic resistance to kanamycin, streptomycin, ciprofloxacin, ampicillin, vancomycin is substantial [4]
Mechanism of action:
- antiseptic
- has some bacteriostatic & fungistatic action
- inhibits fatty acid synthase
General
enzyme inhibitor
topical antiseptic
Properties
INHIBITS: fatty acid synthase
Database Correlations
PUBCHEM correlations
References
- PubChem: 5564
- FDA News Release, April 8, 2010
FDA Provides Information to Consumers about the Ingredient
Triclosan
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm207833.htm
- FDA Consumer Update
Triclosan: What Consumers Should Know
http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm205999.htm
- APRIL 8, 2010: MARKEY URGES BAN ON ANTIMICROBIAL CHEMICAL IN
CONSUMER SOAPS, FOLLOWING FDA CONCERNS
http://markey.house.gov/index.php?option=content&task=view&id=3964&Itemid=125
- Cherednichenko G et al
Triclosan impairs excitation-contraction coupling and Ca2+
dynamics in striated muscle.
PNAS August 13, 2012
PMID: 22891308
http://www.pnas.org/content/early/2012/08/08/1211314109.abstract#aff-1
- Westfall C, Flores-Mireles AL, Robinson JI et al.
The widely used antimicrobial triclosan induces high levels of
antibiotic tolerance in vitro and reduces antibiotic efficacy up
to 100-fold in vivo
Antimicrob Agents Chemother 2019 Apr 25; 63:5.
PMID: 30782996 Free full text
https://aac.asm.org/content/63/5/e02312-18
Component-of
benzocaine/triclosan
chloroxylenol/triclosan
ethanol/triclosan
miconazole/triclosan
sodium fluoride/triclosan
tolnaftate/triclosan
triclosan/undecylenate