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triclabendazole (Egaten)
Indications:
- treatment of liver flukes, fascioliasis & paragonimiasis
Dosage:
- 2 doses of 10 mg/kg given 12 hours with food
Tabs: 250 mg
Pharmacokinetics:
- volume of distribution: 1 L/kg
- protein binding 96-98%
- 1/2life is 8 hours & 11-14 hours for sulfone & sulfoxide metabolites
- metabolized by CYP1A2 (approximately 64%) into its active sulfoxide metabolite & to a lesser extent by CYP2C9, CYP2C19, CYP2D6, CYP3A, & FMO
- the sulfoxide metabolite is further metabolized primarily by CYP2C9 to the active sulfone metabolite & to a lesser extent by CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 & CYP3A4
- in animals, the drug is largely excreted via the biliary tract in the feces (90%), together with the sulfoxide & sulfone metabolite
- < 10% of an oral dose is excreted in the urine
Adverse effects:
- headache, abdominal pain, musculoskeletal chest pain
- urticaria, pruritus, hyperhidrosis
- nausea, vomiting, diarrhea, decreased appetite
Notes:
- treatment in hospital may be required
General
antihelmintic
Database Correlations
PUBCHEM correlations
References
- Wikipedia: Triclabendazole
https://en.wikipedia.org/wiki/Triclabendazole
- HIGHLIGHTS OF PRESCRIBING INFORMATION
EGATENTM (triclabendazole) tablets
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf