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trichilemmoma

Etiology: - Cowden syndrome Pathology: - benign tumor derived from the outer root sheath epithelium of a hair follicle - it consist of cells with pale-staining cytoplasm with abundant glycogen [1] - lobular downgrowth of cells with clear, expanded, faintly glassy cytoplasm [2] Clinical manifestations: - multiple asymptomatic facial papules (case report) [2] - flesh-colored papules localized to the central face * images [2] Special laboratory: - shave biopsy Management: - topical sirolumus, 0.2%, gel daily (maybe 1 year of treatment) [2] - may be used in combination with erbium-yttrium aluminum garnet laser therapy [2]

Related

Cowden's disease; multiple hamartoma syndrome including Lhermitte-Duclos disease (cerebelloparenchymal disorder)

General

glandular epithelial neoplasm

References

  1. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
  2. Bhanot A, Harrell K, Levin J. Treatment of Trichilemmomas With Topical Sirolimus. JAMA Dermatol. Published online January 4, 2023 PMID: 36598777 https://jamanetwork.com/journals/jamadermatology/fullarticle/2800121