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thyrotropin-releasing hormone receptor; TRH-R; thyroliberin receptor (TRHR)
Function:
- receptor for thyrotropin-releasing hormone
- activity mediated by G proteins which activate a phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 398 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-28}
MOTIF: N-glycosylation site {N3}
N-glycosylation site {N10}
transmembrane domain {29-51}
cytoplasmic loop {52-61}
transmembrane domain {62-83}
exoplasmic loop {84-99}
MOTIF: cysteine residue {C98}
MODIFICATION: cysteine residue {C179}
transmembrane domain {100-121}
cytoplasmic loop {122-144}
transmembrane domain {145-168}
exoplasmic loop {169-193}
MOTIF: cysteine residue {C179}
MODIFICATION: cysteine residue {C98}
transmembrane domain {194-215}
cytoplasmic loop {216-266}
transmembrane domain {267-288}
exoplasmic loop {289-296}
transmembrane domain {297-319}
cytoplasmic domain {320-398}
Database Correlations
OMIM 188545
UniProt P34981
Pfam PF00001
Kegg hsa:7201
References
UniProt :accession P34981