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Bax inhibitor 1; BI-1; testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6 (TMBIM6, BI1, TEGT)
Function:
- suppressor of apoptosis
- in mammalian cells, Bl-1 inhibits apoptosis induced by bax, growth factor deprivation, etoposide & staurosporine, but not fas.
- interacts with BCL2 & BCL2L1/BCLX
- BI-1 can interact with bcl-2 & bcl-XL but not bax or bak
Structure:
- belongs to the BI1 family
- BI-1 is predicted to contain 6 or 7 transmembrane domains
- found to be essentially identical to TEGT (testis enhanced gene transcript)
Compartment:
- membrane (potential)
Expression:
- highly abundant in testis
General
anti apoptotic protein
transmembrane 6 protein
Properties
SIZE: entity length = 237 aa
MW = 27 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {30-50}
transmembrane domain {53-73}
transmembrane domain {87-107}
transmembrane domain {113-133}
transmembrane domain {140-160}
transmembrane domain {167-187}
Database Correlations
OMIM 600748
UniProt P55061
Pfam PF01027
Entrez Gene 7009
Kegg hsa:7009
References
- UniProt :accession P55061
- Xu Q & Reed JC
Bax inhibitor-1, a mammalian apoptosis suppressor identified
by functional screening in yeast.
Molecular Cell 1:337-46, 1998
PMID: 9660918