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translin (TSN)
Function:
- DNA-binding protein
- specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments
- seems to recognize single-stranded DNA ends generated by staggered breaks occuring at recombination hot spots
- forms a multimeric ring-shaped structure
- interacts with TSNAX
Structure: belongs to the translin family
Compartment: cytoplasm. nucleus
General
DNA-binding protein
Properties
SIZE: entity length = 228 aa
MW = 26 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: DNA-binding motif
leucine zipper
SITE: 177-198
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 600575
UniProt Q15631
Pfam PF01997
Entrez Gene 7247
Kegg hsa:7247
References
UniProt :accession Q15631