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transketolase (TK, TKT)
Function:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
D-ribose 5-phosphate + D-xylulose 5-phosphate
Cofactor:
- binds 1 Ca+2 per subunit (putative)
- binds 1 thiamine pyrophosphate per subunit
Structure:
- homodimer
- belongs to the transketolase family
Pathology:
- implicated in Wernicke-Korsakoff syndrome
Interactions
molecular events
Related
hexose monophosphate shunt, pentose phosphate pathway or phosphogluconate shunt
transketolase 2 (transketolase-like 1, transketolase related protein, TKTL1, TKR, TKT2)
General
Ca+2 binding protein
phosphoprotein
transketolase family protein
Properties
SIZE: entity length = 623 aa
MW = 68 kD
MOTIF: Ca+2-binding site
SITE: 155-155
Ca+2-binding site
SITE: 185-185
Tyr phosphorylation site {Y275}
Thr phosphorylation site {T287}
Database Correlations
OMIM correlations
UniProt P29401
PFAM correlations
KEGG correlations
ENZYME 2.2.1.1
References
- UniProt :accession P29401
- Wikipedia; note=transketolase entry
http://en.wikipedia.org/wiki/transketolase