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transfusion-associated volume overload; transfusion-associated circulatory overload (TACO)
Etiology:
- hypervolemia associated with volume of transfusion & inability excrete excess fluid
- patients with heart failure &/or renal failure
Clinical manifestations:
- respiratory distress within 6-12 hours of transfusion [1]
- positive fluid balance
- elevated central venous pressure
- S3 heart sound
Laboratory:
- serum BNP is elevated [1]
Radiology:
- chest X-ray shows pulmonary edema [1]
Differential diagnosis:
- transfusion-related acute lung injury (TRALI)
- central venous pressure not elevate
- usually occurs more immediately than TACO with concurrent symptoms of fever & hypotension [1]
Related
transfusion-related acute lung injury (TRALI)
General
hypervolemia (extracellular volume overload)
blood transfusion reaction
References
- Medical Knowledge Self Assessment Program (MKSAP) 18,
American College of Physicians, Philadelphia 2018
- Medical Knowledge Self Assessment Program (MKSAP) 20
American College of Physicians, Philadelphia 2025
- Piccin A, Spizzo G, Popovski MA, et al.
Transfusion-associated circulatory overload in gastroenterology.
Blood Transfus. 2021;19:197-204.
PMID: 33000753