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transferrin receptor in serum
Reference interval: 0.85-3.05 mg/L
Clinical significance:
- when used in conjunction with serum ferritin provides sensitive indicator of iron-deficiency, including elderly patients (transferrin is not an acute phase reactant)
- serum transferrin receptor (mg/L)/log serum ferritin (ng/mL) of > 1.5 is considered diagnostic or iron deficiency [1]
- also elevated levels with erythroid proliferation
Increases:
- iron deficiency
- thalassemia
- hemolytic anemia
- polycythemia
Decreases:
- aplastic anemia
- chronic renal failure
Method:
- sandwich enzyme-linked immunosorbent assay (ELISA) using polyclonal antibody
Principle:
- soluble forms of transferrin are released into the blood
- serum levels of transferrin reflect the amount of membranous transferrin, which is inversely related to iron stores
- serum levels of transferrin receptor increase with iron-deficiency, but not with inflammatory disorders
Related
CD71; transferrin receptor 1; TfR1; TfR; TR; Trfr; T9; p90; sTfR (TFRC)
ferritin in serum/plasma
iron-deficiency anemia
Specific
transferrin receptor, soluble in serum
General
special chemistry test
References
- Rimon E, Levy S, Sapir A, Gelzer G, Peled R, Ergas D,
Sthoeger ZM.
Diagnosis of iron deficiency anemia in the elderly by
transferrin receptor-ferritin index.
Arch Intern Med. 2002 Feb 25;162(4):445-9.
PMID: 11863478
- Clinigen; R& D Systems, Minneapolis, MN