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transferrin in serum

Reference values: - Adults: 252-429 mg/dL. Clinical significance: A decreased transferrin level usually indicates an overall decrease in synthesis of protein, but it may represent increased binding of transferrin by histiocytes. In the congenital defect atransferrinemia, a very low level of transferrin is accompanied by iron overload in which excess iron is deposited in the tissues, especially the liver & pancreas. These patients show a severe hypochromic anemia, along with bronze skin, cirrhosis, diabetes mellitus & low plasma transferrin levels. Increases: - pregnancy - estrogen administration - iron-deficiency anemia Decreases: - chronic inflammation - chronic disease - malignancy - multiple myeloma - chronic liver disease - malnutrition - nephrotic syndrome - protein-losing enteropathies - hemochromatosis - atransferrinemia Principle: The Beckman Array Protein System, in conjunction with the Transferrin Reagent Test Kit, is intended for in vitro diagnostic quantitation of Transferrin of biological fluids by rate nephelometry. Transferrin is synthesized in the liver. It is the major beta-globulin in serum protein electrophoresis. Its major function is the transport of iron & the prevention of loss of iron through the kidney. Its binding of iron prevents iron disposition in the tissues during temporary increases in absorbed iron or free iron. It also has bacteriostatic qualities. Transferrin transports iron to its storage site & to the bone marrow. It is not assimilated in the transport, but releases the iron to the target cell. The transferrin is then available for combination with more iron. Specimen: No special patient preparation is required. 200 uL of serum. Store sample in freezer until ready for assay. Highly lipemic samples may result in inaccurate determination & should be redrawn on a fasting patient.

Related

nephelometry serotransferrin; transferrin; Siderophilin; beta-1 metal-binding globulin (TF) transferrin saturation in serum/plasma

General

transferrin in body fluid

References

  1. Bishop, Michael, Duben-von Laufen, Janet R., Fody, Edward: Clinical Chemistry- Principles, Procedures Corrections, p. 596- 597, 1985.
  2. Tietz, Norbert W.: Textbook of Clinical Chemistry, W.B. Saunders Co., Philadelphia, PA, p. 596-597, 1986.
  3. Beckman Array Protein System Operating Manual.
  4. Teitz, Norbert, W.: Fundamentals of Clinical Chemistry, pp. 333- 334, 1987.
  5. Transferrin Laboratory Test Directory ARUP: 50570

Component-of

iron studies iron/transferrin in serum ovarian cancer 5 protein panel transferrin carbodydrate deficient asialo/total in serum/plasma transferrin carbodydrate deficient disialo/total in serum/plasma transferrin carbodydrate deficient monosialo/total in serum/plasma transferrin carbodydrate deficient pentasialo+hexasialo/total in serum/plasma transferrin carbodydrate deficient pentasialo/total in serum/plasma transferrin carbodydrate deficient tetrasialo/total in serum/plasma transferrin carbodydrate deficient trisialo/total in serum/plasma transferrin carbodydrate deficient/total in serum/plasma