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transdermal nitrate
Variety of forms. (also see nitroglycerin)
Dosage:
Ointment: 2% (Nitropaste): Tradenames Nitro-bid, Nitrol.
- 0.5-5 inches every 4-8 hours. Remove every 8/day (to avoid tolerance) [15 mg/inch]. (30 g, 60 g)
Transdermal:
- 1 patch QD. Deponit: 0.2, 0.4 mg/hr. Minitran: 0.1, 0.2, 0.4, 0.6 mg/hr. Nitro-Dur: 0.1, 0.2, 0.3, 0.4, 0.6, 0.8 mg/hr. Nitrodisc: 0.2, 0.3, 0.4 mg/hr. Transderm-Nitro: 0.1, 0.2, 0.4,0.6, 0.8 mg/hr.
Conversion:
- ointment < 1 inch
- patch 0.4 mg/hr
- dinitrate 20 mg TID
Major advantage is that medication can be removed easily.
General
transdermal therapeutic system (TTS, transdermal patch)