Search
transcription factor PML; tripartite motif-containing protein 19; RING finger protein 71 (PML, MYL, RNF71, TRIM19)
Function:
- probable transcription factor
- may play role in recruitment of ELF4 into PML nuclear bodies
- interacts with SIRT1, TOPBP1, TRIM27 & TRIM69
- interacts with the C-terminus of ELF4.
- interacts with Lassa virus Z protein & rabies virus phosphoprotein (putative)
- ubiquitinated; mediated by SIAH1 or SIAH2 & leading to its subsequent proteasomal degradation
- sumoylation on all three sites is required for nuclear body formation
- sumoylation on Lys-160 is a prerequisite for sumoylation on Lys-65
- the PML-RARA fusion protein is not sumoylated
Structure:
- contains 2 B box-type Zn+2 fingers contains 1 RING-type Zn+2 finger
Compartment:
- nucleus, nucleoplasm, cytoplasm
- sumoylated forms localize to the PML nuclear bodies
- the B1 box & the RING finger are also required for this nuclear localization
- isoforms lacking a nuclear localization signal are cytoplasmic
Alternative splicing:
- named isoforms=5
- additional isoforms seem to exist
Pathology:
- chromosomal translocation t(15;17)(q21;q21) involving PML with RARA may be a cause of acute promyelocytic leukemia; the PML breakpoints (type A & type B) lie on either side of an alternatively spliced exon
- autoantibody ? (see Laboratory)
Laboratory:
- PML antibody in serum [3]
Related
AML-M3; acute promyelocytic leukemia
PML gene
Specific
transcription factor PML-1
transcription factor PML-2
transcription factor PML-3
transcription factor PML-3B
transcription factor PML-X or My1 protein
General
DNA-binding protein
proto oncogene protein
ring finger protein
transcription factor (TF)
Properties
SIZE: entity length = 882 aa
MW = 98 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: proline-rich region
SITE: 3-46
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S8}
RING-finger {57-92}
MOTIF: Zn+2-binding site
SITE: 57-57
Zn+2-binding site
SITE: 60-60
Zn+2-binding site
SITE: 72-72
Zn+2-binding site
SITE: 74-74
Zn+2-binding site
SITE: 77-77
Zn+2-binding site
SITE: 80-80
Zn+2-binding site
SITE: 88-88
Zn+2-binding site
SITE: 91-91
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 124-166
EFFECTOR-BOUND: Zn+2
zinc finger B box
SITE: 183-236
EFFECTOR-BOUND: Zn+2
coiled coil {228-253}
Breakpoint {394-395}
Ser phosphorylation site {S403}
nuclear translocation signal {476-490}
Ser phosphorylation site {S504}
Ser phosphorylation site {S505}
Ser phosphorylation site {S512}
Ser phosphorylation site {S518}
Ser phosphorylation site {S527}
Ser phosphorylation site {S530}
Ser phosphorylation site {S535}
Breakpoint {552-553}
Ser phosphorylation site {S560}
Ser phosphorylation site {S561}
Ser phosphorylation site {S562}
Ser phosphorylation site {S565}
Database Correlations
OMIM 102578
UniProt P29590
PFAM correlations
Entrez Gene 5371
Kegg hsa:5371
References
- UniProt :accession P29590
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/PMLID41.html
- Loinc
Component-of
PML NB complex