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transcription factor IID (TFIID)
Function:
- general transcription factor
- binds to TATA box
- required for transcription whether or not TATA box is present
Structure:
- previously described TFIID species either lack or contain TAFII30 (TFIID alpha & TFIID beta respectively)
- TFIID has 13-14 subunits [3]
Interactions
molecular events
General
DNA-binding protein
general transcription factor (basal transcription factor, transcription initiation factor)
multisubunit protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: transcription initiation factor TFIID subunit 13
transcription initiation factor TFIID subunit 12
MOTIF: Thr phosphorylation site {T43}
Ser phosphorylation site {S51}
Thr phosphorylation site {T59}
transcription initiation factor TFIID subunit 11
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S60}
transcription initiation factor TFIID subunit 10
MOTIF: [KR]-[STA]-K {187-189}
transcription initiation factor TFIID subunit 9
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S85}
DNA-binding motif
SITE: 120-137
Ser phosphorylation site {S149}
Ser phosphorylation site {S155}
Ser phosphorylation site {S158}
Thr phosphorylation site {T159}
Thr phosphorylation site {T161}
Thr phosphorylation site {T178}
Ser phosphorylation site {S181}
TATA-box-binding protein
MOTIF: glutamine-rich region {55-95}
MOTIF: glutamine residue (SEVERAL)
consensus repeat {165-241}
consensus repeat {255-332}
p43 transcription factor IID
MOTIF: binding site
FOR-BINDING-OF: transcription initiation factor TFIID subunit 1
transcription initiation factor TFIID subunit 7
MOTIF: [KR]-[STA]-K {3-5}
Ser phosphorylation site {S171}
Ser phosphorylation site {S201}
Ser phosphorylation site {S213}
serine-rich region {227-230}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S227}
Ser phosphorylation site {S228}
Ser phosphorylation site {S229}
Ser phosphorylation site {S230}
coiled coil {244-349}
MOTIF: Ser phosphorylation site {S264}
transcription initiation factor TFIID subunit 2
COMPARTMENT: cell nucleus
MOTIF: lysine-rich region {600-603}
MOTIF: lysine residue (SEVERAL)
histidine-rich region {1143-1171}
MOTIF: histidine residue (SEVERAL)
lysine-rich region {1155-1178}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S1194}
Ser phosphorylation site {S1196}
Ser phosphorylation site {S1198}
transcription initiation factor TFIID subunit 3
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {136-141}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {163-168}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S183}
Ser phosphorylation site {S199}
Ser phosphorylation site {S229}
Ser phosphorylation site {S236}
Ser phosphorylation site {S243}
Ser phosphorylation site {S267}
Ser phosphorylation site {S291}
Ser phosphorylation site {S297}
Ser phosphorylation site {S301}
Thr phosphorylation site {T364}
Ser phosphorylation site {S410}
Ser phosphorylation site {S411}
Ser phosphorylation site {S413}
Ser phosphorylation site {S415}
Thr phosphorylation site {T501}
lysine-rich region {507-746}
MOTIF: lysine residue (SEVERAL)
proline-rich region
SITE: 779-833
MOTIF: proline residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 865-915
EFFECTOR-BOUND: Zn+2
transcription initiation factor TFIID subunit 6
MOTIF: Ser phosphorylation site {S626}
Ser phosphorylation site {S634}
Ser phosphorylation site {S636}
Ser phosphorylation site {S653}
Thr phosphorylation site {T660}
Ser phosphorylation site {S670}
Ser phosphorylation site {S672}
p95 transcription factor IID
MOTIF: binding site
FOR-BINDING-OF: transcription initiation factor TFIID subunit 1
transcription initiation factor TFIID subunit 5
MOTIF: glycine-rich region {46-49}
LisH {92-124}
lysine-rich region {399-407}
MOTIF: lysine residue (SEVERAL)
WD repeat {468-507}
WD repeat {541-580}
WD repeat {583-624}
WD repeat {625-666}
WD repeat {667-706}
WD repeat {709-748}
transcription initiation factor TFIID subunit 4B
MOTIF: TAFH {256-353}
P65/RELA interaction {511-533}
nuclear export signal {516-556}
Ser phosphorylation site {S595}
Histone-fold {653-702}
coiled coil {722-787}
TAF12 interaction {830-862}
transcription initiation factor TFIID subunit 4
MOTIF: histidine-rich region {39-42}
MOTIF: histidine residue (SEVERAL)
alanine-rich region {52-57}
MOTIF: alanine residue (SEVERAL)
glycine-rich region {98-101}
alanine-rich region {142-148}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 270-277
MOTIF: proline residue (SEVERAL)
alanine-rich region {333-339}
MOTIF: alanine residue (SEVERAL)
TAFH {590-687}
MOTIF: proline-rich region
SITE: 682-685
MOTIF: proline residue (SEVERAL)
alanine-rich region {810-815}
MOTIF: alanine residue (SEVERAL)
transcription initiation factor TFIID subunit 1
STATE: active state
MOTIF: kinase domain
SITE: 1-414
MOTIF: ATP-binding site
NAME: ATP-binding site
Ser phosphorylation site {S137}
proline-rich region
SITE: 157-165
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S307}
HMG box
SITE: 1195-1273
ASF1A/ASF1B {1342-1629}
MOTIF: nuclear translocation signal {1351-1358}
cysteine residue {C1364}
MODIFICATION: cysteine residue {C1619}
bromodomain {1397-1467}
kinase domain
SITE: 1425-1872
MOTIF: ATP-binding site
NAME: ATP-binding site
bromodomain {1520-1590}
cysteine residue {C1619}
MODIFICATION: cysteine residue {C1364}
acidic region {1627-1872}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S1826}
References
- Alberts et al Molecular Biology of the Cell, 2nd ed.
1989, pg 566
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 293
- Chiang CM, Roeder RG.
Cloning of an intrinsic human TFIID subunit that interacts
with multiple transcriptional activators.
Science. 1995 Jan 27;267(5197):531-6.
PMID: 7824954
- http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=109626&PREVIOUS_ID=75856
Component-of
transcriptional initiation complex
Components
p43 transcription factor IID
p95 transcription factor IID (p95TFIID)
TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; transcription initiation factor TFIID TBP subunit; p38TFIID; p38tau (TBP, GTF2D1, TF2D, TFIID)
transcription initiation factor TFIID subunit 10; STAF28; transcription initiation factor TFIID 30 kD subunit; TAF(II)30; TAFII-30; TAFII30 (TAF10, TAF2A, TAF2H, TAFII30)
transcription initiation factor TFIID subunit 11; TFIID subunit p30-beta; transcription initiation factor TFIID 28 kD subunit; TAF(II)28; TAFII-28; TAFII28 (TAF11, TAF2I, PRO2134, p28TFIID)
transcription initiation factor TFIID subunit 12; transcription initiation factor TFIID 20/15 kD subunits; TAFII-20/TAFII-15; TAFII20/TAFII15 (TAF12, TAF15, TAF2J, TAFII20)
transcription initiation factor TFIID subunit 13; transcription initiation factor TFIID 18 kD subunit; TAF(II)18; TAFII-18; TAFII18 (TAF13, TAF2K, TAFII18, p18TFIID)
transcription initiation factor TFIID subunit 1; cell cycle gene 1 protein; TBP-associated factor 250 kD; p250; transcription initiation factor TFIID 250 kD subunit; TAF(II)250; TAFII-250; TAFII250 (TAF1, BA2R, CCG,1 CCGS, TAF2A)
transcription initiation factor TFIID subunit 2; 150 kD cofactor of initiator function; RNA polymerase II TBP-associated factor subunit B; TBP-associated factor 150 kDa; transcription initiation factor TFIID 150 kD subunit; TAF(II)150; TAFII-150; TAFII150 (TAF2, CIF150, TAF2B)
transcription initiation factor TFIID subunit 3; 140 kD TATA box-binding protein-associated factor; TBP-associated factor 3; transcription initiation factor TFIID 140 kD subunit; TAF(II)140; TAF140; TAFII-140; TAFII140 (TAF3)
transcription initiation factor TFIID subunit 4; p136TFIID; RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; transcription initiation factor TFIID 130 kD subunit; TAF(II)130; TAFII-130; TAFII130; transcription initiation factor TFIID 135 kD subunit; TAF(II)135; TAFII-135; TAFII135 (TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135)
transcription initiation factor TFIID subunit 4B; p105TFIID; transcription initiation factor TFIID 105 kD subunit; TAF(II)105; TAFII-105; TAFII105 (TAF4B, TAF2C2, TAFII105)
transcription initiation factor TFIID subunit 5; p100TFIID; transcription initiation factor TFIID 100 kD subunit; TAF(II)100; TAFII-100; TAFII100 (TAF5, TAF2D)
transcription initiation factor TFIID subunit 6; p70TFIID; RNA polymerase II TBP-associated factor subunit E; transcription initiation factor TFIID 70 kD subunit; TAF(II)70; TAFII-70; TAFII70; transcription initiation factor TFIID 80 kD subunit; TAF(II)80; TAFII-80; TAFII80 (TAF6, TAF2E, TAFII70)
transcription initiation factor TFIID subunit 7; RNA polymerase II TBP-associated factor subunit F; transcription initiation factor TFIID 55 kD subunit; TAF(II)55; TAFII-55; TAFII55 (TAF7, TAF2F, TAFII55)
transcription initiation factor TFIID subunit 9; RNA polymerase II TBP-associated factor subunit G; STAF31/32; transcription initiation factor TFIID 31 kD subunit; TAFII-31; TAFII31; transcription initiation factor TFIID 32 kD subunit; TAFII-32; TAFII32 (TAF9, TAF2G, TAFII31)