Search
tumor necrosis factor (TNF) receptor-associated factor 6; interleukin 1 signal transducer; RING finger protein 85 (TRAF6, RNF85)
Function:
1) adapter protein & signal transducer
2) links members of the TNF receptor family to different signaling pathways
3) IL-1 signaling pathway via MYD88 & IRAK kinases
4) IL-17 signaling (putative)
5) activation of NF-kappa-B & JNK (putative)
6) E3 ubiquitin ligase (putative)
7) binds to TNFRSF5, TNFRSF11A, NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRIP, TRAF, TTRAP, UBE2V1
8) interacts with IL17R, SQSTM1, PELI1, PELI2, PELI3, MAVS, TAX1BP1
* see figure
Compartment: cytoplasm
Expression:
- expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas
Interactions
molecular events
General
ring finger protein
tumor necrosis factor [TNF]-alpha receptor-associated factor (TRAF)
Properties
SIZE: MW = 60 kD
entity length = 522 aa
MOTIF: interaction with TAX1BP1. {1-354}
MOTIF: RING-finger {70-109}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger
SITE: 150-202
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 203-259
EFFECTOR-BOUND: Zn+2
coiled coil {288-348}
MATH {350-499}
References
- Entrez Gene :accession 7189
- UniProt :accession Q9Y4K3
Component-of
molecular complex
Databases & Figures
OMIM 602355
UniProt Q9Y4K3
PFAM correlations
Entrez Gene 7189
Figures/diagrams/slides/tables related to TNF receptor-associated factor 6