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TNF receptor-associated factor 5; RING finger protein 84 (TRAF5 RNF84)
Function:
- adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases
- mediates activation of NF-kappa-B & probably JNK
- seems to be involved in apoptosis
- homotrimer (probable)
- heteromer with TRAF3
- associates with TNFRSF5/CD40 through interaction with TRAF3
- associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, & TRAF & TNF receptor-associated protein TTRAP
Structure:
- the MATH/TRAF domain binds to receptor cytoplasmic domains
- contains 1 MATH domain
- contains 1 RING-type Zn+2 finger
- contains 2 TRAF-type Zn+2 fingers
Compartment: cytoplasm (probable)
Expression:
- expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, & peripheral blood
Interactions
molecular events
General
ring finger protein
tumor necrosis factor [TNF]-alpha receptor-associated factor (TRAF)
Properties
SIZE: entity length = 557 aa
MW = 64 kD
COMPARTMENT: cytoplasm
MOTIF: RING-finger {45-85}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger
SITE: 127-181
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 182-239
EFFECTOR-BOUND: Zn+2
coiled coil {237-342}
MATH {403-549}
Database Correlations
OMIM 602356
UniProt O00463
PFAM correlations
Entrez Gene 7188
Kegg hsa:7188
References
- UniProt :accession O00463
- Entrez Gene :accession 7188
Component-of
molecular complex