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tumor necrosis factor (TNF) receptor-associated factor 4; cysteine-rich domain associated with RING & Traf domains protein 1; malignant 62; RING finger protein 83 (TRAF4, CART1, MLN62, RNF83)
Function:
1) adapter protein & signal transducer
2) links members of the TNF receptor family to different signaling pathways
2) activation of NF-kappa-B, JNK (putative) apoptosis
3) development of respiratory tract
Compartment: cytoplasm, nucleus
Expression:
- expressed in epithelial cells of thymus, dendritic cells of lymph node, basal cell layer of epithelia including epidermis, nasopharynx, respiratory tract, salivary gland, esophagus
General
tumor necrosis factor [TNF]-alpha receptor-associated factor (TRAF)
zinc finger protein
Properties
SIZE: MW = 54 kD
entity length = 470 aa
MOTIF: RING-finger {18-58}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger
SITE: 102-154
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 155-208
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 209-266
EFFECTOR-BOUND: Zn+2
coiled coil {277-309}
MATH {307-462}
Database Correlations
OMIM 602464
UniProt Q9BUZ4
PFAM correlations
Entrez Gene 9618
References
- Entrez Gene :accession 9618
- UniProt :accession Q9BUZ4