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TNF receptor-associated factor 3; CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein; LAP1; CAP-1 (TRAF3, CAP1, CRAF1)

Function: - adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases - thought to transmit signal of CD40 - seems to be involved in activation of NF-kappa-B & JNK & in apoptosis - regulated by TANK/ITRAF which competes with TNFRSF5/CD40 for binding - seems to play a role T-cell dependent immune responses homotrimer (probable) - heteromer with TRAF5 - binds to TNFRSF5/CD40 - associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF17/BCMA & EDAR, MAP3K5, MAP3K14, & TRAF-interacting protein TRIP & TRAF & TNF receptor-associated protein TTRAP - binds to TANK/ITRAF & TRAF3IP1 - interacts with TICAM1 (putative) - interacts with OTUD5 Structure: - the MATH/TRAF domain binds to receptor cytoplasmic domains - contains 1 MATH domain - contains 1 RING-type Zn+2 finger - contains 2 TRAF-type Zn+2 fingers Compartment: cytoplasm (probable)

Related

TRAF3 gene mutation; CRAF1 gene mutation

General

ring finger protein tumor necrosis factor [TNF]-alpha receptor-associated factor (TRAF)

Properties

SIZE: entity length = 568 aa MW = 64 kD COMPARTMENT: cytoplasm MOTIF: RING-finger {68-77} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Zinc finger NAME: Zinc finger SITE: 135-190 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 191-249 EFFECTOR-BOUND: Zn+2 coiled coil {267-338} MATH {415-560}

Database Correlations

OMIM 601896 UniProt Q13114 PFAM correlations Entrez Gene 7187 Kegg hsa:7187

References

  1. Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8. PMID: 7533327
  2. Entrez Gene :accession 7187
  3. UniProt :accession Q13114
  4. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/TRAF3ID271.html