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TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor-associated protein 3 (TRAF2, TRAP3)

Function: - adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases - thought to transmit signal of TNF-receptor 2 - association to the receptor is also mediated by the interaction with TRADD - mediates activation of NF-kappa-B & JNK & is involved in apoptosis - the TRAF1/TRAF2 complex recruits apoptotic suppressors BIRC2 & BIRC3 to TNFRSF1B/TNFR2 - seems to be involved in IL-15 signaling - ubiquitinated; mediated by SIAH2 & leading to its subsequent proteasomal degradation - not ubiquitinated by SIAH1 - homotrimer (probable) - heteromer with TRAF1 - binds to TNFRSF1B/TNFR2, TNFRSF4 & TNFRSF5/CD40 - associates with CD27, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, IL15RA, TANK/ITRAF, RIPK2, TNIK, MAP3K14, MAP3K5, MAP3K1, MAP4K2, CDK9, CSK, & TRAF-interacting protein TRAIP & TRAF & TNF receptor-associated protein TTRAP - interacts with TNFAIP3 & TRPC4AP - interacts with PEG3 (putative) - binds to TRADD - interacts with BIRC2 & BIRC3 N-terminus - interacts with CYLD & TBK1 - interacts with MAVS/IPS1 - interacts with CASP8AP2 & USP48 - interacts with DAB2IP - interacts with NFATC2IP & with HIVEP3 (putative) Structure: - the coiled coil domain mediates homo- & hetero- oligomerization - the MATH/TRAF domain binds to receptor cytoplasmic domains - contains 1 MATH domain - contains 1 RING-type Zn+2 finger - contains 2 TRAF-type Zn+2 fingers Compartment: cytoplasm Alternative splicing: named isoforms=2

Interactions

molecular events

General

ring finger protein tumor necrosis factor [TNF]-alpha receptor-associated factor (TRAF)

Properties

SIZE: entity length = 501 aa MW = 56 kD COMPARTMENT: cytoplasm MOTIF: RING-finger {34-73} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Zinc finger NAME: Zinc finger SITE: 124-180 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 177-233 EFFECTOR-BOUND: Zn+2 coiled coil {299-348} MATH {351-496}

References

  1. Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8. PMID: 7533327
  2. Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996 Jan 26;84(2):299-308. PMID: 8565075
  3. Entrez Gene :accession 7186
  4. UniProt :accession Q12933
  5. SeattleSNPs http://pga.gs.washington.edu/data/traf2/

Component-of

molecular complex

Databases & Figures

OMIM 601895 UniProt Q12933 PFAM correlations Entrez Gene 7186 KEGG correlations Figures/diagrams/slides/tables related to TNF receptor-associated factor 2