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TNF receptor-associated factor 1; epstein-Barr virus-induced protein 6 (TRAF1, EBI6)
Function:
- adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases
- thought to transmit signal of TNF-receptor 2
- mediates activation of NF-kappa-B & JNK & is involved in apoptosis
- the TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 & BIRC3 to TNFRSF1B/TNFR2 homotrimer (probable)
- heteromer with TRAF2 & associates with TNFRSF1B/TNFR2 through TRAF2
- associates with TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP & RIPK2
- interacts with BIRC2 & BIRC3 N-terminus
- interacts with NFATC2IP & with HIVEP3 (putative)
Structure:
- the coiled coil domain mediates homo- & hetero- oligomerization
- the MATH/TRAF domain binds to receptor cytoplasmic domains
- contains 1 MATH domain
Related
CD120b; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor 2; TNF-R2; tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; p75TNF receptor; TBPII; TBP-2 (TNFRSF1B, TNFBR, TNFR2)
General
tumor necrosis factor [TNF]-alpha receptor-associated factor (TRAF)
Properties
SIZE: entity length = 416 aa
MW = 46 kD
MOTIF: coiled coil {182-264}
MATH {266-412}
Database Correlations
OMIM 601711
UniProt Q13077
Pfam PF00917
Entrez Gene 7185
Kegg hsa:7185
References
- Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S,
Baltimore D.
Involvement of CRAF1, a relative of TRAF, in CD40 signaling.
Science. 1995 Mar 10;267(5203):1494-8.
PMID: 7533327
- Entrez Gene :accession 7185
- UniProt :accession Q13077