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tumor necrosis factor receptor superfamily member 19; Toxicity & JNK inducer; TRADE (TNFRSF19, TAJ, TROY, UNQ1888/PRO4333)
Function:
- can mediate activation of JNK & NF-kappa-B
- may promote caspase-independent cell death
- associates with TRAF1, TRAF2, TRAF3 & TRAF5
- interacts with LINGO1
Structure: contains 3 TNFR-Cys repeats
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- highly expressed in prostate
- detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon & peripheral blood leukocytes
General
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 423 aa
MW = 46 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-29}
TNFR-Cys {33-72}
MOTIF: cysteine residue {C34}
MODIFICATION: cysteine residue {C46}
cysteine residue {C46}
MODIFICATION: cysteine residue {C34}
cysteine residue {C49}
MODIFICATION: cysteine residue {C62}
cysteine residue {C52}
MODIFICATION: cysteine residue {C72}
cysteine residue {C62}
MODIFICATION: cysteine residue {C49}
cysteine residue {C72}
MODIFICATION: cysteine residue {C52}
TNFR-Cys {74-114}
MOTIF: cysteine residue {C75}
MODIFICATION: cysteine residue {C89}
cysteine residue {C89}
MODIFICATION: cysteine residue {C75}
cysteine residue {C92}
MODIFICATION: cysteine residue {C106}
cysteine residue {C95}
MODIFICATION: cysteine residue {C114}
N-glycosylation site {N105}
cysteine residue {C106}
MODIFICATION: cysteine residue {C92}
cysteine residue {C114}
MODIFICATION: cysteine residue {C95}
TNFR-Cys {116-149}
MOTIF: cysteine residue {C117}
MODIFICATION: cysteine residue {C135}
cysteine residue {C135}
MODIFICATION: cysteine residue {C117}
cysteine residue {C138}
MODIFICATION: cysteine residue {C149}
cysteine residue {C149}
MODIFICATION: cysteine residue {C138}
transmembrane domain {171-191}
Database Correlations
OMIM 606122
UniProt Q9NS68
Pfam PF00020
Entrez Gene 55504
Kegg hsa:5550
References
UniProt :accession Q9NS68