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bosentan (Tracleer)
Indications:
-> treatment of pulmonary hypertension (FDA approved 2001)
Monitor:
- liver function tests baseline & monthly for duration of treatment [2,3]
Adverse effects:
- hepatotoxicity [2,3]
Mechanism of action:
-> endothelin inhibitor
Notes: Manufacturer: Actelion
Interactions
drug interactions
drug adverse effects of antihypertensive agents
Related
endothelin
General
endothelin receptor antagonist
Database Correlations
PUBCHEM correlations
References
- Prescriber's Letter 9(2):S1 2002
- FDA Medwatch
http://www.fda.gov/medwatch/safety/2006/safety06.htm#Tracleer
- Prescriber's Letter 17(7): 2010
Recommended Lab Monitoring for Common Medications
Liver Function Test Scheduling
Detail-Document#: 260704
(subscription needed) http://www.prescribersletter.com